Scientific publications
Variably Protease-Sensitive Prionopathy: Two New Cases With Motor Neuron-Dementia Syndrome
The study shows that prion properties are conserved without post-translational modifications. An international team led by researchers from IRTA-CReSA and CIC bioGUNE has shown that the fastest known prion strain, CWD-vole, maintains its properties even in the absence of glycosylation and membrane anchoring. Using...
Spontaneous generation of diverse recombinant prion strains: sulfated glycan cofactors facilitate strain emergence but do not determine specific strain properties
The study shows that prion properties are conserved without post-translational modifications. An international team led by researchers from IRTA-CReSA and CIC bioGUNE has shown that the fastest known prion strain, CWD-vole, maintains its properties even in the absence of glycosylation and membrane anchoring. Using...
The Risk of Transmission of Genetic Prion Diseases is Greater Than 50%
The study shows that prion properties are conserved without post-translational modifications. An international team led by researchers from IRTA-CReSA and CIC bioGUNE has shown that the fastest known prion strain, CWD-vole, maintains its properties even in the absence of glycosylation and membrane anchoring. Using...
A comprehensive phylogeny of mammalian PRNP gene reveals no influence of prion misfolding propensity on the evolution of this gene
The study shows that prion properties are conserved without post-translational modifications. An international team led by researchers from IRTA-CReSA and CIC bioGUNE has shown that the fastest known prion strain, CWD-vole, maintains its properties even in the absence of glycosylation and membrane anchoring. Using...
Effect of primary structural variation on cervid prion protein in flexibility, stability, and spontaneous misfolding propensity
Cofactors favour prion misfolding, but are not essential to generate infectivity A multidisciplinary team led by researchers from CIC bioGUNE and in collaboration with partners from the NEURO-COOP project, has demonstrated that the prion protein [...]
Characterization of prion strains and peripheral prion infectivity patterns in E200K genetic CJD patients
Researchers from the Centre for Encephalopathies and Emerging Communicable Diseases of the University of Zaragoza, within the framework of the NEURO-COOP project, have managed to detect prions (PrP^Sc) in the oocytes and ovaries of sheep naturally infected with classical scrapie, using the ultra-sensitive PMCA (Protein Misfolding Cyclic Amplification) technique.
Detection of prions in oocytes and ovaries of ewes naturally infected with classical scrapie
Researchers from the Centre for Encephalopathies and Emerging Communicable Diseases of the University of Zaragoza, within the framework of the NEURO-COOP project, have managed to detect prions (PrP^Sc) in the oocytes and ovaries of sheep naturally infected with classical scrapie, using the ultra-sensitive PMCA (Protein Misfolding Cyclic Amplification) technique.
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