Scientific publications
A comprehensive phylogeny of mammalian PRNP gene reveals no influence of prion misfolding propensity on the evolution of this gene
The study shows that prion properties are conserved without post-translational modifications. An international team led by researchers from IRTA-CReSA and CIC bioGUNE has shown that the fastest known prion strain, CWD-vole, maintains its properties even in the absence of glycosylation and membrane anchoring. Using...
Effect of primary structural variation on cervid prion protein in flexibility, stability, and spontaneous misfolding propensity
Cofactors favour prion misfolding, but are not essential to generate infectivity A multidisciplinary team led by researchers from CIC bioGUNE and in collaboration with partners from the NEURO-COOP project, has demonstrated that the prion protein [...]
Characterization of prion strains and peripheral prion infectivity patterns in E200K genetic CJD patients
Researchers from the Centre for Encephalopathies and Emerging Communicable Diseases of the University of Zaragoza, within the framework of the NEURO-COOP project, have managed to detect prions (PrP^Sc) in the oocytes and ovaries of sheep naturally infected with classical scrapie, using the ultra-sensitive PMCA (Protein Misfolding Cyclic Amplification) technique.
Detection of prions in oocytes and ovaries of ewes naturally infected with classical scrapie
Researchers from the Centre for Encephalopathies and Emerging Communicable Diseases of the University of Zaragoza, within the framework of the NEURO-COOP project, have managed to detect prions (PrP^Sc) in the oocytes and ovaries of sheep naturally infected with classical scrapie, using the ultra-sensitive PMCA (Protein Misfolding Cyclic Amplification) technique.
Conservation of strain properties of bank vole-adapted chronic wasting disease in the absence of glycosylation and membrane anchoring
The study shows that prion properties are conserved without post-translational modifications. An international team led by researchers from IRTA-CReSA and CIC bioGUNE has shown that the fastest known prion strain, CWD-vole, maintains its properties even in the absence of glycosylation and membrane anchoring. Using...
Cofactors facilitate bona fide prion misfolding in vitro but are not necessary for the infectivity of recombinant murine prions
Cofactors favour prion misfolding, but are not essential to generate infectivity A multidisciplinary team led by researchers from CIC bioGUNE and in collaboration with partners from the NEURO-COOP project, has demonstrated that the prion protein [...]
Zoonotic Potential of Chronic Wasting Disease after Adaptation in Intermediate Species
A strain of chronic wasting disease in elk shows increased zoonotic potential after passage through sheep An international study led by French scientists, ...
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