Mood disturbances could be an early sign of Creutzfeldt-Jakob disease

Author: Eva Fernández-Muñoz Creutzfeldt-Jakob disease (CJD) is a rare and rapidly progressive neurodegenerative disorder caused by the misfolding of the cellular prion protein (PrPC) into a misfolded form called PrPSc, which accumulates in the brain, causing neuronal damage and spongiform degeneration. The sporadic form (sCJD) is the most common form, accounting for approximately [...]

ION717 clinical trial completes patient enrolment

Author: Eric Minikel (translated by Joaquín Castilla) Ionis Pharmaceuticals has announced (see original letter) this morning that it has completed enrolment of PrProfile, its Phase 1/2a clinical trial of ION717, an ASO drug designed to reduce PrP levels in prion diseases. The study is now listed as "Active, without [...]

Scientists discover early brain alterations in people at risk of developing hereditary Creutzfeldt-Jakob disease

Author: Cristina Sampedro Prion diseases can occur spontaneously or genetically, the latter being caused by a mutation in the prion protein (PrP), which are rare but devastating neurodegenerative disorders that affect both humans and animals. The main types of genetic prion diseases are genetic Creutzfeldt-Jakob disease (gCJD), genetic Creutzfeldt-Jakob disease (gCJD), genetic Creutzfeldt-Jakob disease (gCJD), genetic [...]

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