Mood disturbances could be an early sign of Creutzfeldt-Jakob disease

Author: Eva Fernández-Muñoz Creutzfeldt-Jakob disease (CJD) is a rare and rapidly progressive neurodegenerative disorder caused by the misfolding of the cellular prion protein (PrPC) into a misfolded form called PrPSc, which accumulates in the brain, causing neuronal damage and spongiform degeneration. The sporadic form (sCJD) is the most common form, accounting for approximately [...]
The Spanish Foundation for Prion Diseases submits its application to the Ministry of Health for the inclusion of prion diseases in the ELA Act.

Author: Joaquín Castilla An essential step in the defence of the rights of patients and their families In an effort to guarantee the recognition and protection of the rights of people affected by prion diseases, the Spanish Foundation for Prion Diseases has exercised its right to participate in the Prior Public Consultation [...]
New strategies to understand and combat sporadic Creutzfeldt-Jakob disease through integration of genetic data

Author: Nuno Anjo Sporadic Creutzfeldt-Jakob disease (sCJD) is a rare, fatal and rapidly progressive neurodegenerative disease for which there are still no effective treatments. It is characterised by the misfolding of the normal prion protein (PrPC) into an abnormal form called PrPSc or Prion, which accumulates in the brain, causing neuronal damage [...].
ION717 clinical trial completes patient enrolment

Author: Eric Minikel (translated by Joaquín Castilla) Ionis Pharmaceuticals has announced (see original letter) this morning that it has completed enrolment of PrProfile, its Phase 1/2a clinical trial of ION717, an ASO drug designed to reduce PrP levels in prion diseases. The study is now listed as "Active, without [...]
Scientists discover early brain alterations in people at risk of developing hereditary Creutzfeldt-Jakob disease

Author: Cristina Sampedro Prion diseases can occur spontaneously or genetically, the latter being caused by a mutation in the prion protein (PrP), which are rare but devastating neurodegenerative disorders that affect both humans and animals. The main types of genetic prion diseases are genetic Creutzfeldt-Jakob disease (gCJD), genetic Creutzfeldt-Jakob disease (gCJD), genetic Creutzfeldt-Jakob disease (gCJD), genetic [...]
Expansion and reactivation of Ionis PrProfile (ION717) clinical trial for people with symptomatic prion disease

Author: Joaquín Castilla Ionis Pharmaceuticals has just announced that the recruitment pause for its PrProfile (ION717) study for people with symptomatic prion disease has been lifted. Important information to note: Resumption of recruitment: After a planned pause, recruitment for the PrProfile clinical trial has resumed as of [...]
New international study looks for correlations between genetic variations and sporadic CJD

Author: Josu Galarza Scientists from around the world have collaborated on a genetic study that seeks to identify small changes in the genome that may be related to the clinical development and age of onset of sporadic Creutzfeldt-Jakob disease (sCJD). Prion diseases are classified as rare diseases due to their low incidence [...].